enzyme substrate enzyme_genesymbol substrate_genesymbol residue_type residue_offset modification sources references Q12933 Q13546 TRAF2 RIPK1 K 377 ubiquitination SIGNOR SIGNOR:18621737;SIGNOR:21232017;SIGNOR:8702708;SIGNOR:9712898 Q8IUD6 O95786 RNF135 RIGI K 907 ubiquitination SIGNOR SIGNOR:19017631 Q8IUD6 O95786 RNF135 RIGI K 909 ubiquitination SIGNOR SIGNOR:19017631 P60604 Q92813 UBE2G2 DIO2 K 237 ubiquitination SIGNOR SIGNOR:29892818 P60604 Q92813 UBE2G2 DIO2 K 244 ubiquitination SIGNOR SIGNOR:29892818 Q13489 Q13546 BIRC3 RIPK1 K 377 ubiquitination SIGNOR SIGNOR:16603398;SIGNOR:18570872;SIGNOR:18621737 Q96J02 Q7Z434 ITCH MAVS K 420 ubiquitination SIGNOR SIGNOR:19881509 Q96J02 Q7Z434 ITCH MAVS K 371 ubiquitination SIGNOR SIGNOR:19881509 Q66K89 P04637 E4F1 TP53 K 319 ubiquitination HPRD;SIGNOR HPRD:17110336;SIGNOR:17110336 Q66K89 P04637 E4F1 TP53 K 321 ubiquitination HPRD;SIGNOR HPRD:17110336;SIGNOR:17110336 Q66K89 P04637 E4F1 TP53 K 320 ubiquitination HPRD HPRD:17110336 Q12933 O43318 TRAF2 MAP3K7 K 158 ubiquitination SIGNOR SIGNOR:20038579 Q9C0C9 O43541 UBE2O SMAD6 K 173 ubiquitination SIGNOR SIGNOR:23455153 O15033 Q9NR28 AREL1 DIABLO K 191 ubiquitination SIGNOR SIGNOR:31732561 O15033 Q9NR28 AREL1 DIABLO K 62 ubiquitination SIGNOR SIGNOR:31732561 Q9Y4K3 O43318 TRAF6 MAP3K7 K 34 ubiquitination SIGNOR SIGNOR:18758450 Q9Y385 Q92813 UBE2J1 DIO2 K 244 ubiquitination SIGNOR SIGNOR:29892818 Q9Y385 Q92813 UBE2J1 DIO2 K 237 ubiquitination SIGNOR SIGNOR:29892818 Q9H0X6 P08670 RNF208 VIM K 97 ubiquitination SIGNOR SIGNOR:31862882 P14373 A8K0Z3 TRIM27 WASHC1 K 220 ubiquitination SIGNOR SIGNOR:23452853 Q9Y4K3 P51617 TRAF6 IRAK1 K 134 ubiquitination SIGNOR SIGNOR:18347055 Q9Y4K3 P51617 TRAF6 IRAK1 K 180 ubiquitination SIGNOR SIGNOR:18347055 Q99942 Q86WV6 RNF5 STING1 K 150 ubiquitination SIGNOR SIGNOR:19285439 Q8NG06 O95786 TRIM58 RIGI K 172 ubiquitination SIGNOR SIGNOR:23499489 Q9UKB1 P25963 FBXW11 NFKBIA K 21 ubiquitination SIGNOR SIGNOR:7479976;SIGNOR:9990853 Q9UKB1 P25963 FBXW11 NFKBIA K 22 ubiquitination SIGNOR SIGNOR:7479976;SIGNOR:9990853 Q969H0 P23769 FBXW7 GATA2 T 176 ubiquitination SIGNOR SIGNOR:25670854 P55072 O95786 VCP RIGI K 181 ubiquitination SIGNOR SIGNOR:26471729 P49459 P12004 UBE2A PCNA K 164 ubiquitination SIGNOR SIGNOR:12226657;SIGNOR:19706603 Q8NHY2 Q53ET0 COP1 CRTC2 K 629 ubiquitination SIGNOR SIGNOR:17805301 Q8NHY2 Q53ET0 COP1 CRTC2 K 212 ubiquitination SIGNOR SIGNOR:17805301 Q7L5Y6 Q53ET0 DET1 CRTC2 K 629 ubiquitination SIGNOR SIGNOR:17805301 Q7L5Y6 Q53ET0 DET1 CRTC2 K 212 ubiquitination SIGNOR SIGNOR:17805301 P62877 Q53ET0 RBX1 CRTC2 K 629 ubiquitination SIGNOR SIGNOR:17805301 P62877 Q53ET0 RBX1 CRTC2 K 212 ubiquitination SIGNOR SIGNOR:17805301 Q13619 Q53ET0 CUL4A CRTC2 K 629 ubiquitination SIGNOR SIGNOR:17805301 Q13619 Q53ET0 CUL4A CRTC2 K 212 ubiquitination SIGNOR SIGNOR:17805301 Q16531 Q53ET0 DDB1 CRTC2 K 629 ubiquitination SIGNOR SIGNOR:17805301 Q16531 Q53ET0 DDB1 CRTC2 K 212 ubiquitination SIGNOR SIGNOR:17805301 P63279 O75030 UBE2I MITF K 308 ubiquitination SIGNOR SIGNOR:10673502 Q9H0M0 Q9Y2J4 WWP1 AMOTL2 K 347 ubiquitination SIGNOR SIGNOR:34404733 Q9H0M0 Q9Y2J4 WWP1 AMOTL2 K 408 ubiquitination SIGNOR SIGNOR:34404733 Q99942 Q7Z434 RNF5 MAVS K 362 ubiquitination SIGNOR SIGNOR:20483786 Q99942 Q7Z434 RNF5 MAVS K 461 ubiquitination SIGNOR SIGNOR:20483786 Q9Y297 P10071 BTRC GLI3 K 784 ubiquitination SIGNOR SIGNOR:17283082 Q9Y297 P10071 BTRC GLI3 K 800 ubiquitination SIGNOR SIGNOR:17283082 Q9Y297 P10071 BTRC GLI3 K 779 ubiquitination SIGNOR SIGNOR:17283082 Q9Y297 P10071 BTRC GLI3 K 773 ubiquitination SIGNOR SIGNOR:17283082 Q8IYW5 P16104 RNF168 H2AX K 14 ubiquitination SIGNOR SIGNOR:22980979 Q969V5 P31749 MUL1 AKT1 K 284 ubiquitination SIGNOR SIGNOR:22410793 Q8N653 P01116 LZTR1 KRAS K 170 ubiquitination SIGNOR SIGNOR:30442762 O60260 O43175 PRKN PHGDH K 330 ubiquitination SIGNOR SIGNOR:32478681 Q96PU5 P35240 NEDD4L NF2 K 396 ubiquitination SIGNOR SIGNOR:33058421 O94874 P62805 UFL1 H4C8 K 32 ubiquitination SIGNOR SIGNOR:30886146 Q00987 P25098 MDM2 GRK2 K 19 ubiquitination HPRD HPRD:17006543 Q00987 P25098 MDM2 GRK2 K 21 ubiquitination HPRD HPRD:17006543 Q00987 P25098 MDM2 GRK2 K 30 ubiquitination HPRD HPRD:17006543 Q00987 P25098 MDM2 GRK2 K 31 ubiquitination HPRD HPRD:17006543 Q00987 P04637 MDM2 TP53 K 373 ubiquitination HPRD HPRD:11094089;HPRD:17110336 Q8N2H9 P51617 PELI3 IRAK1 K 134 ubiquitination HPRD HPRD:18326498 P46934 P51170 NEDD4 SCNN1G K 10 ubiquitination HPRD HPRD:9351815 P46934 P51170 NEDD4 SCNN1G K 12 ubiquitination HPRD HPRD:9351815 P46934 P51170 NEDD4 SCNN1G K 13 ubiquitination HPRD HPRD:9351815 P46934 P51170 NEDD4 SCNN1G K 26 ubiquitination HPRD HPRD:9351815 P46934 P51170 NEDD4 SCNN1G K 6 ubiquitination HPRD HPRD:9351815 P46934 P51170 NEDD4 SCNN1G K 8 ubiquitination HPRD HPRD:9351815 P40337 Q16665 VHL HIF1A K 532 ubiquitination HPRD HPRD:10944113 Q9H1A4 O95997 ANAPC1 PTTG1 K 9 ubiquitination HPRD HPRD:11179223 Q9NX47 Q9NX47 MARCHF5 MARCHF5 C 65 ubiquitination HPRD HPRD:16874301 Q9NX47 Q9NX47 MARCHF5 MARCHF5 C 68 ubiquitination HPRD HPRD:16874301